Early Antiretroviral Therapy Reduces AIDS Progression/Death in Individuals with Acute Opportunistic Infections: A Multicenter Randomized Strategy Trial

@article{Zolopa2009EarlyAT,
  title={Early Antiretroviral Therapy Reduces AIDS Progression/Death in Individuals with Acute Opportunistic Infections: A Multicenter Randomized Strategy Trial},
  author={Andrew R. Zolopa and Janet A Andersen and Lauren Komarow and Ian Sanne and Alejandro Sanchez and Evelyn Hogg and Carol Suckow and William G. Powderly},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={27 - 34}
}
BACKGROUND Optimal timing of ART initiation for individuals presenting with AIDS-related OIs has not been defined. METHODS AND FINDINGS A5164 was a randomized strategy trial of "early ART"--given within 14 days of starting acute OI treatment versus "deferred ART"--given after acute OI treatment is completed. Randomization was stratified by presenting OI and entry CD4 count. The primary week 48 endpoint was 3-level ordered categorical variable: 1. Death/AIDS progression; 2. No progression with… CONTINUE READING
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