Early Alzheimer's and Parkinson's Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the Evidence

@inproceedings{CalderonGarciduenas2013EarlyAA,
  title={Early Alzheimer's and Parkinson's Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the Evidence},
  author={Lilian C. Calderon-Garciduenas and Maricela Franco-Lira and Antonieta Mora-Tiscare{\~n}o and Humberto Medina-Cortina and Ricardo Torres-Jard{\'o}n and Michael P. Kavanaugh},
  booktitle={BioMed research international},
  year={2013}
}
Chronic exposure to particulate matter air pollution is known to cause inflammation leading to respiratory- and cardiovascular-related sickness and death. Mexico City Metropolitan Area children exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, and innate and adaptive immune responses. Early dysregulated neuroinflammation, brain microvascular damage, production of potent vasoconstrictors, and perturbations in the integrity of the neurovascular unit likely… CONTINUE READING
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