Early Adherence to Antiretroviral Medication as a Predictor of Long-Term HIV Virological Suppression: Five-Year Follow Up of an Observational Cohort

@article{Ford2010EarlyAT,
  title={Early Adherence to Antiretroviral Medication as a Predictor of Long-Term HIV Virological Suppression: Five-Year Follow Up of an Observational Cohort},
  author={Nathan P Ford and Marta Darder and Tim Spelman and Emilou Maclean and Edward J. Mills and Andrew Boulle},
  journal={PLoS ONE},
  year={2010},
  volume={5},
  url={https://api.semanticscholar.org/CorpusID:6914732}
}
This longitudinal study provides further confirmation of adherence as a primary determinant of subsequent confirmed virological failure, and serves as a reminder of the importance of initial early investments in adherence counseling and support as an effective way to maximize long-term treatment success.
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25 References

Relationship between adherence level, type of the antiretroviral regimen, and plasma HIV type 1 RNA viral load: a prospective cohort study.

Assessment of the relationship between adherence, antiretroviral regimen, and viral load (VL) suppression was assessed among 1142 HIV-infected patient found less than 95% of adherence is associated with high virologic success.

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The relative ease of administration of the 30-day visual analog scale suggests that this may be the preferred method to assess adherence in resource-poor settings.

Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time

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The effect of baseline CD4+ cell count and adherence on survival rates after the initiation of HAART was evaluated and it was suggested that delaying HAART after the CD4- cell count declines below 0.350 109 cells/L may be unsafe.

HIV type-1 clade C resistance genotypes in treatment-naive patients and after first virological failure in a large community antiretroviral therapy programme

Prevalence of primary resistance in a sample of ART-naive clade C HIV-1-infected individuals in South Africa was low during the study period, and individual genotypes in those failing first-line therapy should be considered.