Earlier onset of tumoral angiogenesis in matrix metalloproteinase-19-deficient mice.

@article{Jost2006EarlierOO,
  title={Earlier onset of tumoral angiogenesis in matrix metalloproteinase-19-deficient mice.},
  author={Maud Jost and Alicia R. Folgueras and Françoise Fr{\'e}rart and Alberto M Pend{\'a}s and Sylvia Blacher and Xavier Houard and Sarah Ann Berndt and Carine Munaut and Didier Cataldo and Jesus I. Murillo Alvarez and Laurence Melen-Lamalle and Jm. Foidart and Carlos L{\'o}pez-Ot{\'i}n},
  journal={Cancer research},
  year={2006},
  volume={66 10},
  pages={
          5234-41
        }
}
Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during malignant transformation and dedifferentiation. The contribution of MMP-19 during tumor angiogenesis is presently unknown. In an attempt to give new insights into MMP-19 in vivo functions, angiogenic response of mutant mice lacking MMP-19 was analyzed after transplantation of murine malignant… CONTINUE READING

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