Eag1 Expression Interferes with Hypoxia Homeostasis and Induces Angiogenesis in Tumors*S⃞

@article{Downie2008Eag1EI,
  title={Eag1 Expression Interferes with Hypoxia Homeostasis and Induces
 Angiogenesis in
 Tumors*S⃞},
  author={Bryan R. Downie and Araceli S{\'a}nchez and Hendrik Knoetgen and Constanza Contreras-Jurado and Marco Gymnopoulos and Claudia Weber and Walter Stuehmer and Luis A Pardo},
  journal={The Journal of Biological Chemistry},
  year={2008},
  volume={283},
  pages={36234 - 36240}
}
Ether-á-go-go-1 (Eag1) is a CNS-localized voltage-gated potassium channel that is found ectopically expressed in a majority of extracranial solid tumors. While circumstantial evidence linking Eag1 to tumor biology has been well established, the mechanisms by which the channel contributes to tumor progression remain elusive. In this study, we have used in vivo and in vitro techniques to identify a candidate mechanism. A mutation that eliminates ion permeation fails to completely abolish… CONTINUE READING

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