Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.

@article{Rossetto2014Eaf573FA,
  title={Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.},
  author={Dorine Rossetto and Myriam Cramet and Alice Y. Wang and Anne-Lise Steunou and Nicolas Lacoste and Julia M. Schulze and Val{\'e}rie C{\^o}t{\'e} and Julie Monnet-Saksouk and Sandra Piquet and Amine Nourani and Michael S. Kobor and Jacques C{\^o}t{\'e}},
  journal={The EMBO journal},
  year={2014},
  volume={33 12},
  pages={1397-415}
}
The NuA4 histone acetyltransferase complex is required for gene regulation, cell cycle progression, and DNA repair. Dissection of the 13-subunit complex reveals that the Eaf7 subunit bridges Eaf5 with Eaf3, a H3K36me3-binding chromodomain protein, and this Eaf5/7/3 trimer is anchored to NuA4 through Eaf5. This trimeric subcomplex represents a functional module, and a large portion exists in a native form outside the NuA4 complex. Gene-specific and genome-wide location analyses indicate that… CONTINUE READING

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The NuA4 histone acetyltransferase complex is required for gene regulation , cell cycle progression , and DNA repair .
The NuA4 histone acetyltransferase complex is required for gene regulation , cell cycle progression , and DNA repair .
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