Each peptide of the two-component lantibiotic lacticin 3147 requires a separate modification enzyme for activity.

@article{Mcauliffe2000EachPO,
  title={Each peptide of the two-component lantibiotic lacticin 3147 requires a separate modification enzyme for activity.},
  author={O Mcauliffe and Colin Hill and R Paul Ross},
  journal={Microbiology},
  year={2000},
  volume={146 ( Pt 9)},
  pages={2147-54}
}
The genetic determinants for production and immunity to the two-component lantibiotic lacticin 3147 are encoded by a 12.6 kb region of the plasmid pMRC01. This region contains ten genes arranged in two divergent clusters; these include the structural genes and a number of genes whose products show significant similarity to proteins involved in the biosynthesis of other lantibiotics. Using a strategy of deletion and mutational analysis, the effect of disruption of a number of these genes was… CONTINUE READING

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