Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

@article{Fraser1993EachHS,
  title={Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.},
  author={Paul Fraser and Sara Pruzina and Michael N Antoniou and Frank Grosveld},
  journal={Genes & development},
  year={1993},
  volume={7 1},
  pages={106-13}
}
We have tested the effect of the individual DNase I hypersensitive site (HS) regions of the globin locus control region (LCR) on the developmental expression pattern of the human gamma and beta genes in transgenic mice. The results show that HS3 is the most active site during the embryonic period. It is also the only site capable of high level expression of the gamma genes during fetal hematopoiesis, in a population of cells that are capable of expressing both the gamma and beta genes. Region… CONTINUE READING