EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

@article{Rondinelli2017EZH2PD,
  title={EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation},
  author={Beatrice Rondinelli and Ewa Gogola and Hatice Y{\"u}cel and Alexandra Alves Duarte and Marieke van de Ven and Roxanne van der Sluijs and Panagiotis Konstantinopoulos and Jos Jonkers and Rapha{\"e}l Ceccaldi and Sven Rottenberg and Alan D' Andrea},
  journal={Nature Cell Biology},
  year={2017},
  volume={19},
  pages={1371-1378}
}
The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers. Dissecting the molecular pathways controlling genomic stability at stalled forks is critical. Here we show that EZH2 localizes at stalled forks where it methylates Lys27 on histone… CONTINUE READING
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