EZH2 is essential for glioblastoma cancer stem cell maintenance.

  title={EZH2 is essential for glioblastoma cancer stem cell maintenance.},
  author={Mario-Luca Suv{\`a} and Nicol{\`o} Riggi and Michalina Janiszewska and Ivan Radovanovic and Paolo Provero and J C Stehle and Karine Baumer and Marie-Aude Le Bitoux and Denis Marino and Luisa Cironi and Victor E. Marquez and Virginie Cl{\'e}ment and Ivan Stamenkovic},
  journal={Cancer research},
  volume={69 24},
Overexpression of the polycomb group protein enhancer of zeste homologue 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and glioblastoma multiforme (GBM). Based on its ability to modulate transcription of key genes implicated in cell cycle control, DNA repair, and cell differentiation, EZH2 is believed to play a crucial role in tissue-specific stem cell maintenance and tumor development. Here, we show that targeted pharmacologic disruption of EZH2 by the S… CONTINUE READING
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