EZH2 as a therapeutic target in solid tumors


Epigenetic alterations are an important hallmark of cancer, and the enzymes that modify histone tails have emerged as attractive drug targets. The histone methyltransferase EZH2 is the catalytic subunit of PRC2, a highly conserved protein complex that regulates gene expression by methylating lysine 27 on histone H3. EZH2 is frequently overexpressed in… (More)


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@inproceedings{Barsotti2015EZH2AA, title={EZH2 as a therapeutic target in solid tumors}, author={Anthony M. Barsotti and Michael Ryskin and P T Kung and Dominique Verhelle and Robert A. Rollins}, year={2015} }