EXTRACORPOREAL IRRADIATION OF THE BLOOD IN HUMANS: EFFECTS UPON ERYTHROCYTE SURVIVAL

@article{Schiffer1966EXTRACORPOREALIO,
  title={EXTRACORPOREAL IRRADIATION OF THE BLOOD IN HUMANS: EFFECTS UPON ERYTHROCYTE SURVIVAL},
  author={L. Schiffer and H. Atkins and A. Chanana and E. Cronkite and M. Greenberg and H. A. Johnson and J. Robertson and P. Stryckmans},
  journal={Blood},
  year={1966},
  volume={27},
  pages={831-843}
}
Autologous erythrocytes were irradiated at doses of 35,000 to 200,000 rads, chromated, and red cell survival studied. The 24-hour loss of labeled cells and subsequent apparent erythrocyte survival times were found to be functions of the radiation dose. ECIB-produced red cell hemolysis of a mild degree is to be expected during courses of therapy, as demonstrated by clinical findings. However, there is no doubt that acute, severe, hemolysis could be produced by administering large doses to… Expand
Haemolysis in patients with chronic lymphocytic leukaemia during extracorporeal irradiation of the blood.
TLDR
Erythrocyte destruction was studied in six patients with chronic lymphocytic leukaemia treated with extracorporeal irradiation of the blood (ECI), and 59Fe-data were suggestive of random destruction of erythrocytes in four of the six patients. Expand
Rationale and recommendations for the irradiation of blood products.
TLDR
It is concluded that 1500 rad is sufficient to prevent lymphocyte proliferation and production of graft-vs-host disease in vivo, although 10 to 20% of lymphocytes are still capable of proliferation in vitro after 1500 rad. Expand
Extracorporeal irradiation of blood (ECIB) in man. II. Treatment of acute myelocytic leukemia.
TLDR
The usefulness of this mode of treatment in the overall management of AML is uncertain, although it might be considered as an alternative form of therapy for patients in whom chemotherapy is contra-indicated and to prevent leukostasis. Expand
Deformability and viability of irradiated red cells.
TLDR
A critical examination of the literature and the results indicate that the erythrocyte deformability is the only parameter related to viability to show sufficiently precocious and important changes. Expand
Survival of DF32P-labelled erythrocytes in uraemic patients during extracorporeal irradiation of the blood.
TLDR
The fact that the median Hb concentration in the blood decreased slightly but significantly in a further 15 patients during ECIB indicates that ECIB may induce a slight reduction in red cell survival in severely uraemic patients. Expand
Evaluation of extracorporeal alkylation of red cells as a potential treatment for sickle cell anemia.
TLDR
If alkylating agents are used to treat patients' cells, inhibition of sickling may outweigh the shortening of red cell life span induced by the treatment; blood should probably be irradiated before infusion to avoid administration of alkylated and potentially mutated, but viable, lymphocytes. Expand
Evaluation of extracorporeal alkylation of red cells as a potential treatment for sickle cell anemia.
TLDR
If alkylating agents are used to treat patients' cells, inhibition of sickling may outweigh the shortening of red cell life span induced by the treatment; blood should probably be irradiated before infusion to avoid administration of alkylated and potentially mutated, but viable, lymphocytes. Expand
Effects of irradiation on human platelets stored at 20°C
Summary The morphologic and functional properties of platelets after irradiation with 2500 rads and storage, infirst-generation containers, for 48h in a liquid phase at 20°C with continuousExpand
Extracorporeal irradiation of the blood in baboons.
TLDR
Continuous extracorporeal irradiation of the blood (ECI) for 10 to 21 days was carried out in baboons by means of an x-ray irradiator without a pump or anticoagulation to observe Prompt, pronounced, and long-lasting lymphocytopenia was observed. Expand
[Extracorporeal irradiation of the blood].
  • E. Weeke
  • Medicine
  • Il Policlinico. Sezione pratica
  • 1969
TLDR
A direct relationship was found between the transit dose and the development and degree of lymphopenia for transit doses between 100 and 500 rads for patients undergoing extracorporeal irradiation of the blood. Expand
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