EXTRACELLULAR VESICLES: CLASSIFICATION, FUNCTIONS AND CLINICAL RELEVANCE

@article{Oberemko2014EXTRACELLULARVC,
  title={EXTRACELLULAR VESICLES: CLASSIFICATION, FUNCTIONS AND CLINICAL RELEVANCE},
  author={A. Oberemko and A. Popandopulo},
  journal={Biotechnologia Acta},
  year={2014},
  volume={7},
  pages={102-108}
}
This review presents a generalized definition of vesicles as bilayer extracellular organelles of all cellular forms of life: not only eu-, but also prokaryotic. The structure and composition of extracellular vesicles, history of research, nomenclature, their impact on life processes in health and disease are discussed. Moreover, vesicles may be useful as clinical instruments for biomarkers, and they are promising as biotechnological drug. However, many questions in this area are still… Expand
Exosomes as a novel cell‐free therapeutic approach in gastrointestinal diseases
TLDR
This review considers the main defined biogenesis, function, and component of secreted exosome in different cells with a specific focus on the potential application of these exosomes as a cell‐free therapeutic approach in gastrointestinal diseases like IBD, gastric cancer, and colon cancer. Expand
Extracellular vesicles: novel communicators in lung diseases
TLDR
This comprehensive review focuses on what is currently known about the role of EVs as markers and mediators of lung pathologies including COPD, pulmonary hypertension, asthma, lung cancer and ALI/ARDS and explores the role EVs can potentially serve as therapeutics for these lung diseases when released from healthy progenitor cells, such as mesenchymal stem cells. Expand
Exosomes: Biogenesis, Composition, Functions, and Their Role in Pre-metastatic Niche Formation
TLDR
This review mainly focuses on exosome biogenesis, composition, their biological and pathological functions, and roles in pre-metastatic niche formation. Expand
Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia.
TLDR
It can be suggested that syncytiotrophoblast extracellular vesicles from preeclamptic pregnancies may support the exaggerated inflammatory state during preeclampsia. Expand
Probable Role of Non-exosomal Extracellular Vesicles in Colorectal Cancer Metastasis to Kidney: An In Vitro Cell Line Based Study and Image Analysis
Metastasis of colorectal carcinoma to the kidney is a rare phenomenon and least-investigated mechanistically. Both exosomal and non-exosomal vesicles (NEVs) from tumor tissues have been proven to beExpand
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis.
TLDR
Results suggest that hucMSC-Ex could ameliorate CCl4-induced liver fibrosis by inhibiting EMT and protecting hepatocytes, which provides a novel approach for the treatment of fibrotic liver disease. Expand

References

SHOWING 1-10 OF 63 REFERENCES
Classification, Functions, and Clinical Relevance of Extracellular Vesicles
TLDR
Evidence is accumulating that vesicles are cargo containers used by eukaryotic cells to exchange biomolecules as transmembrane receptors and genetic information, and they have a myriad of potential clinical applications, ranging from biomarkers to anticancer therapy. Expand
Extracellular Vesicles in Multiple Sclerosis: What are They Telling Us?
TLDR
The pathological role of EVs in MS and the relationship of EVs with clinical characteristics, therapy, and biomarkers of the disease are summarized. Expand
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
TLDR
The need for standardization of specimen handling, appropriate normative controls, and isolation and analysis techniques to facilitate comparison of results is emphasized, and it is recognized that continual development and evaluation of techniques will be necessary as new knowledge is amassed. Expand
Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity.
TLDR
Support to apply proteomics in the study of extracellular vesicles released by well-controlled in vitro cellular systems to identify low invasive markers for diseases is strongly supported. Expand
MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease.
TLDR
The role of microvesicles in cell-to-cell communication in general and in specific interactions between cells in chronic inflammation associated with atherosclerotic disease is discussed and changes in microRNA content rather than protein or lipid content are emphasized. Expand
Exosomal miRNAs as potential biomarkers of cardiovascular risk in children
TLDR
Insight is provided into the composition and functional properties of exosomes, and their potential value as diagnostic markers in the context of cardiovascular disease risk estimates in children who suffer from conditions associated with heightened prevalence of adverse cardiovascular disease, namely obesity and sleep-disordered-breathing. Expand
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
TLDR
It is concluded that cancer cell-derived exosomes use heparan sulfate proteoglycans (HSPGs) for their internalization and functional activity, which significantly extends the emerging role of HSPGs as key receptors of macromolecular cargo. Expand
Exosomes as mediators of neuroinflammation
TLDR
Novel therapeutic strategies are being developed that exploit the biology of these vesicles to deliver anti-inflammatory molecules to the CNS and alter the way the authors think about brain disorders and their treatments. Expand
Cellular Mechanisms Underlying the Formation of Circulating Microparticles
TLDR
Because PS exposure is a key feature in pathological processes different from hemostasis and thrombosis, the most important obstacle in the field of MP-modulating drugs seems to be carefully targeting MP release to relevant cell types at an optimal level, so as to achieve a beneficial action and limit possible adverse effects. Expand
Heparan sulfate proteoglycan as a cell-surface endocytosis receptor.
TLDR
The intriguing role of H SPGs as a major entry pathway of macromolecules in mammalian cells is discussed with emphasis on recent in vitro and in vivo data that provide compelling evidence of HSPG as an autonomous endocytosis receptor. Expand
...
1
2
3
4
5
...