EXPRESSION OF CYCLOOXYGENASE-2 IN THE MACULA DENSA OF HUMAN KIDNEY IN HYPERTENSION, CONGESTIVE HEART FAILURE, AND DIABETIC NEPHROPATHY

@article{Khan2001EXPRESSIONOC,
  title={EXPRESSION OF CYCLOOXYGENASE-2 IN THE MACULA DENSA OF HUMAN KIDNEY IN HYPERTENSION, CONGESTIVE HEART FAILURE, AND DIABETIC NEPHROPATHY},
  author={K. N. Khan and A. Burke and K. Stanfield and Robert K. Harris and D. Baron},
  journal={Renal Failure},
  year={2001},
  volume={23},
  pages={321 - 330}
}
Cyclooxygenase-2 (COX-2) is constitutively expressed in the macula densa of several laboratory animal species where it is considered to play a physiologic role in the regulation of basal renal function. Pertubations to normal homeostasis is shown to be associated with the upregulation of COX-2 in the macula densa of rats and dogs. In contrast, COX-2 has not been detected in the macula densa of normal adult human and non-human primate kidneys, suggesting a less prominent role of this isoform in… Expand
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