EXPERIENCES IN THE POLYPEPTIDE FIELD: INSULIN TO OXYTOCIN

@article{Vigneaud1960EXPERIENCESIT,
  title={EXPERIENCES IN THE POLYPEPTIDE FIELD: INSULIN TO OXYTOCIN},
  author={V. D. Vigneaud},
  journal={Annals of the New York Academy of Sciences},
  year={1960},
  volume={88}
}
  • V. D. Vigneaud
  • Published 1960
  • Chemistry
  • Annals of the New York Academy of Sciences
It has been my privilege for the past 35 years to have witnessed, anL a t times participated in, a truly exciting development in the field of biochemistry. The development I have in mind involved: first, the recognition and acceptance that a hormone could be a protein or polypeptide; second, the working out of the organic chemical structures of certain polypeptide and protein hormones; third, the demonstration by synthesis of the authenticity of the structures postulated for certain lower… Expand
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A new method of purification of vasopressin’ which has yielded preparations of high potency and a study of the amino acid composition of these preparations is presented. Expand
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The oxytocic and pressor activities of the human posterior pituitary gland were separated chromatographically after preliminary purification and it is evident that the oxytocin and vasopressin found in the human pituitaries are identified as oxytoc in and arginine vasopressingin. Expand
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In recent years the X-ray crystallographers have made remarkable advances in the interpretation of protein structure, and it is becoming more and more evident that a stage has been reached when theirExpand
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It has been shown that trypsin had no effect on the activity of oxytocin but destroyed both the pressor and oxytocic activities of arginine- vasopressin, and it has also been demonstrated that a lysine-vasoppressin preparation possessed Oxytocic activity and that this activity was destroyed with thePressor activity bytrypsin. Expand
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The physiological activity of the pressor and oxytocic principles of the posterior pituitary gland is not appreciably altered when treated with cysteine, in slightly alkaline solution, in contrast toExpand
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