• Corpus ID: 101472733

EXOSOMAL CURCUMIN: ITS BIOAVAILABILITY AND POTENTIAL ANTI- INFLAMMATION ACTIVITY

@inproceedings{Sun2010EXOSOMALCI,
  title={EXOSOMAL CURCUMIN: ITS BIOAVAILABILITY AND POTENTIAL ANTI- INFLAMMATION ACTIVITY},
  author={Dongmei Sun},
  year={2010}
}

• Dongmei Sun
• Published 2010
• Biology

Curcumin, a pleiotropic polyphenol derived from turmeric plants Curcuma Longa with rhizome, exhibits strong evidence as an anti-inflammation, anti-oxidant and anti-cancer reagent both in vitro and in vivo. Due to its low stability and systemic bioavailability, a large amount of curcumin has to be administrated to achieve therapeutic effects both in animal and in human. The major effort to overcome this barrier is making by encapsulation of curcumin into nanoparticles such as polymers and liposomes; some promising data have demonstrated the effectiveness of such method. Exosomes are vesicle-like nanoparticles secreted by living cells. Exosomes contain both cell surface molecules and cytoplasmic molecules due to endoand exocytosis formation pathways. These properties may make exosomes a well-armed nanoparticles drug carrier when formulated with curcumin. In this study, we showed evidence that curcumin can be encapsulated into exosomes and this encapsulation didn’t disrupt the structure of exosomes. Exosomal curcumin may combine exosomes, curcumin and nanoparticles functions together to be a powerful triple threat. To test this hypothesis, we evaluate the anti-inflammatory activity of exosomal curcumin in comparison with free curcumin alone. Our in vitro studies showed that encapsulation curcumin into exosomes can increase stability and solubility of curcumin, and when RAW cells were treated with