EXCITATION–CONTRACTION COUPLING FROM THE 1950s INTO THE NEW MILLENNIUM

@article{Dulhunty2006EXCITATIONCONTRACTIONCF,
  title={EXCITATION–CONTRACTION COUPLING FROM THE 1950s INTO THE NEW MILLENNIUM},
  author={A. Dulhunty},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2006},
  volume={33}
}
  • A. Dulhunty
  • Published 2006
  • Chemistry, Medicine
  • Clinical and Experimental Pharmacology and Physiology
1 Excitation–contraction coupling is broadly defined as the process linking the action potential to contraction in striated muscle or, more narrowly, as the process coupling surface membrane depolarization to Ca2+ release from the sarcoplasmic reticulum. 2 We now know that excitation–contraction coupling depends on a macromolecular protein complex or ‘calcium release unit’. The complex extends the extracellular space within the transverse tubule invaginations of the surface membrane, across the… Expand
From excitation to intracellular Ca2+ movements in skeletal muscle: Basic aspects and related clinical disorders
  • B. Allard
  • Chemistry, Medicine
  • Neuromuscular Disorders
  • 2018
In skeletal muscle fiber, excitation-contraction coupling corresponds to the sequence of events occurring from action potential firing to initiation of contraction by an increase in cytosolic Ca2+.Expand
Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?
TLDR
Early and recent findings are presented that support and define the role of Cav1.1 as a voltage sensor for ECC, two essential players of ECC in skeletal muscle. Expand
Spatio-temporal calcium dynamics in pacemaking units of the interstitial cells of Cajal.
TLDR
A model of the spatio-temporal calcium dynamics within an ICC pacemaker unit is constructed to determine under what conditions the local calcium concentrations may reduce below baseline. Expand
Depression of voltage-activated Ca2+ release in skeletal muscle by activation of a voltage-sensing phosphatase
Muscle contraction is initiated when action potentials fired at the end-plate of the muscle cells propagate throughout the transverse tubule system and reach a region called the triad where theExpand
In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
Muscle contraction is dependent on a large Ca'+ release from its intracellular Ca+ store, the sarcoplasmic reticulum (SR), through ryanodine receptor Ca+ release channels (RyRs). In the restingExpand
Skeletal muscle excitation-contraction coupling: who are the dancing partners?
TLDR
A major candidate for a role in the coupling mechanism is thebeta subunit of the dihydropyridine receptor, because specific residues in both the beta subunit and ryanodine receptor have been identified that facilitate an interaction between the two proteins and these also impact on excitation-contraction coupling. Expand
Calcium influx through a possible coupling of cation channels impacts skeletal muscle satellite cell activation in response to mechanical stretch.
TLDR
Evidence is added that two ion channels, the mechanosensitive cation channel (MS channel) and the long-lasting-type voltage-gated calcium-ion channel (L-V GC channel), mediate the influx of extracellular calcium ions in response to cyclic stretch in satellite cell cultures, providing an additional insight that calcium ions may flow in through L-VGC channels by possible coupling with adjacent MS channel gating that promotes the local depolarization of cell membranes. Expand
Mechanisms of excitation-contraction uncoupling relevant to activity-induced muscle fatigue.
  • G. Lamb
  • Chemistry, Medicine
  • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2009
TLDR
It appears that the disruption to the coupling occurs at the triad junction, where the voltage-sensor molecules (dihydropyridine receptors) normally interact with and open the Ca2+ release channels (ryanodine receptors) in the adjacent sarcoplasmic reticulum (SR). Expand
Calcium influx through L-type channels attenuates skeletal muscle contraction via inhibition of adenylyl cyclases.
TLDR
Results show that extracellular Ca(2+) modulates skeletal muscle contraction, through inhibition of Ca( 2+)-sensitive AC, and the cross-talk between Extracellular calcium and cAMP-dependent signaling pathways appears to regulate the extent of skeletal Muscle contraction responses. Expand
Local calcium signals induced by hyper-osmotic stress in mammalian skeletal muscle cells
TLDR
The results point to a modulatory, even though not essential, role of the DHP receptor for osmotic stress-induced Ca signals in skeletal muscle. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 115 REFERENCES
Involvement of dihydropyridine receptors in excitation–contraction coupling in skeletal muscle
TLDR
It is reported here that low concentrations of a dihydropyridine inhibit charge movements and SR calcium release in parallel, and it is proposed specifically that the molecule that generates charge movement is the dihydopyridine receptor. Expand
Junctional membrane structure and store operated calcium entry in muscle cells.
  • J. Ma, Z. Pan
  • Chemistry, Medicine
  • Frontiers in bioscience : a journal and virtual library
  • 2003
TLDR
Results indicate that SOC activation requires an intact interaction between PM and SR, and is linked to conformational changes of ryanodine receptors, and may add to the Ca2+ needed for muscle contraction under conditions of intensive exercise and fatigue. Expand
Sarcoplasmic reticulum contains adenine nucleotide-activated calcium channels
TLDR
Single-channel recordings of calcium release channels from purified ‘heavy’ SR membranes are reported here on the basis of their activation by adenine nucleotides, blockade by ruthenium red, and selectivity for divalent cations. Expand
Regions of the skeletal muscle dihydropyridine receptor critical for excitation–contraction coupling
TLDR
The results obtained indicate that the putative cytoplasmic region between repeats II and III of the skeletal muscle DHP receptor3 is an important determinant of skeletal-type EC coupling. Expand
Calcium release from the sarcoplasmic reticulum.
TLDR
A review of the mechanism of Ca release from the SR of cardiac muscle and this is compared to release in skeletal muscle, and two processes have been proposed as possible links between the action potential of the sarcolemma and the release of Ca from theSR: the Ca-induced release ofCa and the "depolarization-induced"release of Ca. Expand
Ryanodine receptor/Ca2+ release channels and their regulation by endogenous effectors.
  • G. Meissner
  • Chemistry, Medicine
  • Annual review of physiology
  • 1994
TLDR
Foot structures have been termed feet and are now commonly known as ryanodine receptor/Ca2+ release channels because of the presence of an intrinsic ci+ channel activity within the feet structures, and their ability to bind the plant. Expand
Localization of Ca2+ release channels with ryanodine in junctional terminal cisternae of sarcoplasmic reticulum of fast skeletal muscle.
TLDR
Direct binding studies with [3H]ryanodine provide evidence on the mode of action of ryanodine and its localization to the terminal cisternae and the low concentration at which the drug is effective appears to account for its toxicity. Expand
Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor
TLDR
The results support the possibility of a retrograde signal by which RyR-1 enhances the function of DHPRs as Ca2+ channels, and measurements of charge movement indicate that the density ofDHPRs is similar in dyspedic and Ry R-1-expressing myotubes. Expand
Physical coupling between ryanodine receptor-calcium release channels.
TLDR
It is shown that in reconstituted "checkerboard-like" lattices that mimic in situ membrane channel arrays, each oligomer is interlocked physically with four adjacent oligomers via a specific domain-domain interaction. Expand
Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle
TLDR
The results suggest the presence of a large junctional complex spanning the two junctional membranes and intervening gap, which is an ideal candidate for a mechanical coupling hypothesis of excitation-contraction coupling at the triadic junction. Expand
...
1
2
3
4
5
...