EWS represses cofilin 1 expression by inducing nuclear retention of cofilin 1 mRNA

@article{Huang2014EWSRC,
  title={EWS represses cofilin 1 expression by inducing nuclear retention of cofilin 1 mRNA},
  author={Lv Huang and Iku Kuwahara and Kazuyuki Matsumoto},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={2995-3003}
}
In Ewing’s sarcoma family tumors (ESFTs), the proto-oncogene EWS that encodes an RNA-binding protein is fused by chromosomal translocation to the gene encoding one of the E-twenty six (ETS) family of transcription factors, most commonly friend leukemia virus integration 1 (FLI-1). Although EWS/FLI-1 chimeric proteins are necessary for carcinogenesis, additional events seem to be required for transformation to occur. We have previously reported that a protein product of an EWS mRNA target, whose… CONTINUE READING
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