EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.

@article{lava1998EWSFLI1FT,
  title={EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.},
  author={Enrique de {\'A}lava and Akira Kawai and John H. Healey and I Fligman and PaulA. Meyers and Andrew G. Huvos and William L. Gerald and Suresh C. Jhanwar and Pedram Argani and Cristina R Antonescu and F. J. Pardo-Mind{\'a}n and Jill P. Ginsberg and Richard B. Womer and Elizabeth R Lawlor and Jay S. Wunder and Il Andrulis and Poul Henrik Bredahl Sorensen and F. G. Barr and Marc Ladanyi},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1998},
  volume={16 4},
  pages={
          1248-55
        }
}
PURPOSE More than 90% of Ewing's sarcomas (ES) contain a fusion of the EWS and FLI1 genes, due to the t(11;22)(q24;q12) translocation. At the molecular level, the EWS-FLI1 rearrangements show great diversity. Specifically, many different combinations of exons from EWS and FLI1 encode in-frame fusion transcripts and result in differences in the length and composition of the chimeric protein, which functions as an oncogenic aberrant transcription factor. In the most common fusion type (type 1… CONTINUE READING
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