EWS/FLI-1 oncoprotein subtypes impose different requirements for transformation and metastatic activity in a murine model

@article{Gonzlez2007EWSFLI1OS,
  title={EWS/FLI-1 oncoprotein subtypes impose different requirements for transformation and metastatic activity in a murine model},
  author={Iranzu Gonz{\'a}lez and Silvestre Vicent and Enrique de {\'A}lava and Fernando Lecanda},
  journal={Journal of Molecular Medicine},
  year={2007},
  volume={85},
  pages={1015-1029}
}
Ewing sarcoma/primitive neuroectodermal tumors (EWS/PNET) are characterized by specific chromosomal translocations most often generating a chimeric EWS/FLI-1 gene. Depending on the number of juxtaposed exons assembled, several fusion types have been described with different incidences and prognoses. To assess the impact of each fusion type on the specific phenotypic, tumorigenic, and metastatic features of EWS/PNET, we developed an amenable system using a murine mesenchymal multipotent C3H10T1… CONTINUE READING

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