EWS/ETS Regulates the Expression of the Dickkopf Family in Ewing Family Tumor Cells

@article{Miyagawa2009EWSETSRT,
  title={EWS/ETS Regulates the Expression of the Dickkopf Family in Ewing Family Tumor Cells},
  author={Yoshitaka Miyagawa and Hajime Okita and Mitsuko Itagaki and Masashi Toyoda and Yohko U. Katagiri and Junichiro Fujimoto and Jun-ichi Hata and Akihiro Umezawa and Nobutaka Kiyokawa},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={4020 - 4033}
}
BACKGROUND The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt/beta-catenin signaling and has a crucial role in development. Recent studies have revealed the involvement of this family in tumorigenesis, however their role in tumorigenesis is still remained unclear. METHODOLOGY/PRINCIPAL FINDINGS We found increased expression of DKK2 but decreased expression of DKK1 in Ewing family tumor (EFT) cells. We showed that EFT-specific EWS/ETS fusion proteins… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Mutant screening for oncogenes of Ewing’s sarcoma using yeast

Applied Microbiology and Biotechnology • 2015
View 4 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…