author={Tamiko Oh-hama},
  journal={Origins of life and evolution of the biosphere},
  • T. Oh-hama
  • Published 1 August 1997
  • Biology
  • Origins of life and evolution of the biosphere
Abstract5-Aminolevulinic acid (ALA), a universal precursor of tetrapyrrole compounds can be synthesized by two pathways: the C5 (glutamate) pathway and ALA synthase. From the phylogenetic distribution it is shown that distribution of ALA synthase is restricted to the α subclass of purple bacteria in prokaryotes, and further distributed to mitochondria of eukaryotes. The monophyletic origin of bacterial and eukaryotic ALA synthase is shown by sequence analysis of the enzyme. Evolution of ALA… 
Biosynthesis of Bacteriochlorophylls in Purple Bacteria
The details of the properties of these enzymes from the purple bacteria, such as purification methods and kinetic analyses from the early literature, through to more recent studies using recombinant purple bacterial enzymes.
Molecular cloning and expression pattern of the porcine 5-aminolevulinate synthase 1 ( ALAS 1 ) gene and its association with reproductive traits
The complete coding sequence of the porcine ALAS1 gene and its 2-9 intron sequence is isolated, a single nucleotide polymorphism (SNP; T/C) is identified in intron 9, and a PCR-MspI-restriction fragment length polymorphism genotyping assay is developed.
Mitochondria and Cytoprotection
Mitochondrion is an eukaryotic double-membrane bound organelle that arose from a bacterial endosymbiont that participates in calcium homeostasis, metabolic sensing, innate immunity, autophagy, and cell death regulation.
Biochemical characteristics of alga-bacterial mats and invertebrates from shallow-water hydrothermal fields of the West Pacific Ocean
It is indicated that living conditions near hydrothermal vents accelerate metabolism of bivalves and sea urchins in examined hydroThermal zones in the northern and southern West Pacific Ocean.
Whole-Genome Resequencing of Twenty Branchiostoma belcheri Individuals Provides a Brand-New Variant Dataset for Branchiostoma
This study resequenced 20 Branchiostomabelcheri genomes to an average depth of approximately 12.5X and predicted all potential mutations in intracellular digestion-associated genes, and revealed a population expansion at the Greenlandian stage of the current geological epoch.
Using Gene Essentiality and Synthetic Lethality Information to Correct Yeast and CHO Cell Genome-Scale Models
A comprehensive ES and SL analysis of two important eukaryotic models using a bilevel optimization approach and demonstrates the importance of single and multiple knockout phenotypes in assessing and improving model reconstructions.
Intracellular Replication and Exit Strategies
The melanized Cryptococcus neoformans strain 145 is more resistant to cell death caused by lymphocytes than the less melanized strain 52 and revealed an unexpected role for mitochondrial genes in regulating cryptococcal hypervirulence in the Vancouver Island strains.
Mitochondria: Redox Metabolism and Dysfunction
Generation of reactive oxygen/nitrogen species (ROS/RNS) in the mitochondria, redox regulatory roles of certain mitochondrial proteins, and the impact on cell fate will be discussed.
AMPK Targets Involved in Energy Homeostasis and Epigenetic Regulation of Mitochondrial Function-related Genes
This work is to study a novel mechanism by which AMPK regulates both energy and redox homeostasis through regulation of NAD+ synthetase 1 (NADSYN) and two epigenetic modulators, DNMT1 and retinoblastoma binding protein 7 (RBBP7).


Distribution of δ-aminolevulinic acid biosynthetic pathways among phototrophic bacterial groups
The distribution of the two pathways among the bacteria tested was in general agreement with their previously established phylogenetic relationships and clearly indicates that the five-carbon pathway is the more ancient process, whereas the pathway utilizing ALA synthase probably evolved much later.
Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes.
Theauthenticity of human liver ALAS 1 was demonstrated by its 90% amino acid sequence identity with that of rat liver 6-aminolevulinate synthase (11), and the authenticity of human ALAS2 was demonstratedBy its 90%" amino acid sequences identity with mouse erythroid 6-AML synthase clone MS-6 (12, 13).
Sequence of human 5-aminolevulinate synthase cDNA.
The mitochondrial enzyme, 5-aminolevulinate synthase, catalyses the first step in the heme biosynthetic pathway and is one of the few animal genes shown to be subject to end pro-duct repression (1).
Separate physiological roles and subcellular compartments for two tetrapyrrole biosynthetic pathways in Euglena gracilis.
Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor.
The complete nucleotide sequence of a cDNA clone coding for the precursor is presented together with corresponding confirmatory amino acid sequence of peptides derived from purified mature mitochondrial enzyme.
Incomplete citric acid cycle obliges aminolevulinic acid synthesis via the C5 pathway in a methylotroph
The enzymic activities of the citric acid cycle and the connected pathway of 5-aminolevulinic acid (ALA) formation in the methylotroph Methylophilus methylotrophicus (strain AS1) have been studied and it is suggested that the cycle has no catabolic role and is purely biosynthetic.
Biosynthesis of Δ-aminolevulinate in greening barley leaves. IX. Structure of the substrate, mode of gabaculine inhibition, and the catalytic mechanism of glutamate 1-semialdehyde aminotransferase
The hypothesis is proposed that the enzyme catalyzes the conversion of glutamate 1-semialdehyde to 5-aminolevulinate via 4,5-diaminovalerate via gabaculine in the chloroplast in a complex with pyridoxamine phosphate.