EVOLUTIONARY CONSIDERATION ON 5-AMINOLEVULINATE SYNTHASE IN NATURE

@article{Ohhama2004EVOLUTIONARYCO,
  title={EVOLUTIONARY CONSIDERATION ON 5-AMINOLEVULINATE SYNTHASE IN NATURE},
  author={Tamiko Oh-hama},
  journal={Origins of life and evolution of the biosphere},
  year={2004},
  volume={27},
  pages={405-412}
}
  • T. Oh-hama
  • Published 1 August 1997
  • Biology
  • Origins of life and evolution of the biosphere
Abstract5-Aminolevulinic acid (ALA), a universal precursor of tetrapyrrole compounds can be synthesized by two pathways: the C5 (glutamate) pathway and ALA synthase. From the phylogenetic distribution it is shown that distribution of ALA synthase is restricted to the α subclass of purple bacteria in prokaryotes, and further distributed to mitochondria of eukaryotes. The monophyletic origin of bacterial and eukaryotic ALA synthase is shown by sequence analysis of the enzyme. Evolution of ALA… 
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The distribution of the two pathways among the bacteria tested was in general agreement with their previously established phylogenetic relationships and clearly indicates that the five-carbon pathway is the more ancient process, whereas the pathway utilizing ALA synthase probably evolved much later.
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TLDR
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