Corpus ID: 88040575

EVOLUTION AND SUBSTRATE SPECIFICITY OF CORONAVIRAL AND TOROVIRAL RECEPTOR-DESTROYING ENZYMES*□ S

@inproceedings{Smits2005EVOLUTIONAS,
  title={EVOLUTION AND SUBSTRATE SPECIFICITY OF CORONAVIRAL AND TOROVIRAL RECEPTOR-DESTROYING ENZYMES*□ S},
  author={S. Smits and G. Gerwig and Arno L. W. van Vliet and A. Lissenberg and P. Briza and J. Kamerling and R. Vlasak and R. J. Groot},
  year={2005}
}

• S. Smits, G. Gerwig, +5 authors R. J. Groot
• Published 2005
• Biology

Many viruses achieve reversible attachment to sialic acid (Sia) by encoding envelope glycoproteins with receptor-binding and receptor-destroying activities. Toroviruses and group 2 coronaviruses bind to O-acetylated Sias, presumably via their spike proteins (S), whereas other glycoproteins, the hemagglutinin-esterases (HE), destroy Sia receptors by de-O-acetylation. Here, we present a comprehensive study of these enzymes. Sialate-9-O-acetylesterases specific for 5-N-acetyl-9-Oacetylneuraminic… Expand

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