EVM005: An Ectromelia-Encoded Protein with Dual Roles in NF-κB Inhibition and Virulence

@inproceedings{Buuren2014EVM005AE,
  title={EVM005: An Ectromelia-Encoded Protein with Dual Roles in NF-κB Inhibition and Virulence},
  author={Nicholas van Buuren and Kristin Burles and Jill Schriewer and Ninad Mehta and Scott Parker and R. Mark L. Buller and Michele Barry},
  booktitle={PLoS pathogens},
  year={2014}
}
Poxviruses contain large dsDNA genomes encoding numerous open reading frames that manipulate cellular signalling pathways and interfere with the host immune response. The NF-κB signalling cascade is an important mediator of innate immunity and inflammation, and is tightly regulated by ubiquitination at several key points. A critical step in NF-κB activation is the ubiquitination and degradation of the inhibitor of kappaB (IκBα), by the cellular SCFβ-TRCP ubiquitin ligase complex. We show here… CONTINUE READING
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