EVIENCE THAT IGF 2 INTERFERES WITH THE LYSOSOMAL ENZYME ACTIVITIES OF CARTILAGE CELLS IN VITRO

@article{Poiraudcau1993EVIENCETI,
  title={EVIENCE THAT IGF 2 INTERFERES WITH THE LYSOSOMAL ENZYME ACTIVITIES OF CARTILAGE CELLS IN VITRO},
  author={S Poiraudcau and J Bourguignon and Michele Pagano and Marie Th{\'e}r{\`e}se Corvol},
  journal={Pediatric Research},
  year={1993},
  volume={33},
  pages={S82}
}
In cartilage cells as well as in other cell types, IGF2 is considered as a growth factor mainly mimicking the effect of IGF1 through IGF1-receptor. Since cartilage cells contain both types I and II IGF-receptors, it is still unknown wether IGF2 may have specific effects mediated through the IGF2-Mannose-6-Phosphate receptor (IGF2/M6P-R). This bifunctional protein also binds glycosylated proteins such as newly synthesized acid protease enzymes being responsible of their targeting from me Golgi… CONTINUE READING