EVIDENCE THAT 5‐METHOXY‐N, N‐DIMETHYL TRYPTAMINE IS A SPECIFIC SUBSTRATE FOR MAO‐A IN THE RAT: IMPLICATIONS FOR THE INDOLEAMINE DEPENDENT BEHAVIOURAL SYNDROME

@article{Squires1975EVIDENCET5,
  title={EVIDENCE THAT 5‐METHOXY‐N, N‐DIMETHYL TRYPTAMINE IS A SPECIFIC SUBSTRATE FOR MAO‐A IN THE RAT: IMPLICATIONS FOR THE INDOLEAMINE DEPENDENT BEHAVIOURAL SYNDROME},
  author={Richard Felt Squires},
  journal={Journal of Neurochemistry},
  year={1975},
  volume={24}
}
  • R. Squires
  • Published 1 January 1975
  • Biology, Chemistry
  • Journal of Neurochemistry
A simple method for the separation of 5‐hydroxyindoleacetic acid (5‐HIAA) and 5‐methoxyindoleacetic acid (5‐MeOIAA) on columns of non‐ionic polystyrene (Amberlite XAD‐2) is described. Administration of 5‐methoxy‐N, N‐dimethyl‐tryptamine (5‐MeODMT) 2 mg/kg i. p. to rats results in a sixfold increase in brain 5‐MeOIAA within 15 min. This increase is blocked by the selective inhibitor of MAO‐A, clorgyline, but not by the selective inhibitor of MAO‐B, deprenyl, indicating that 5‐MeODMT is… 
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29 Citations
Highly Influential Citations
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29 Citations

EFFECTS OF MONOAMINE OXIDASE INHIBITION BY CLORGYLINE, DEPRENIL OR TRANYLCYPROMINE ON 5‐HYDROXYTRYPTAMINE CONCENTRATIONS IN RAT BRAIN AND HYPERACTIVITY FOLLOWING SUBSEQUENT TRYPTOPHAN ADMINISTRATION
TLDR
It is concluded that while 5‐HT may normally be metabolized in the brain by ‘Type A’ MAO in vivo, when this form is inhibited,5‐HT can still be metabolitesized by ’Type B’ enzyme.
Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor
TLDR
Deuterated tryptamines may be useful in behavioral and pharmacological studies to mimic the effects of tryptamine/MAOI combinations to indicate that the hyperactivity induced by 5- MeO-DMT after MAO inhibition is a consequence of reduced metabolism of 5-MeO- DMT, leading to prolonged occupation of central serotonin receptors.
Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors
TLDR
The ability of harmaline to modify the behavioral effects of 5-MeO-DMT is mediated by the inhibition of MAOA, and 5-HT2A receptors are responsible for the late hyperactivity induced by 5- MeO- DMT in the presence ofMAOA inhibitors.
Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine
  • A. Halberstadt
  • Biology, Psychology
    Pharmacology Biochemistry and Behavior
  • 2016
Characterization of eight biogenic indoleamines as substrates for type A and type B monoamine oxidase.
Deamination of 5-methoxytryptamine, serotonin and phenylethylamine by rat MAO in vitro and in vivo.
Nonlinear Pharmacokinetics of 5-Methoxy-N,N-dimethyltryptamine in Mice
TLDR
A nonlinear pharmacokinetic property for 5-MeO-DMT in mice is established, suggesting that the risk of 5-Methoxy-N,N,-dimethyltryptamine intoxication may be increased nonproportionally at higher doses.
Distribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection: application of a new solid-phase extraction LC-APcI-MS-MS-isotope dilution method.
Studies of monoamine oxidases. Inhibition of bovine brain MAO in intact mitochondria by selective inhibitors.
SOME PARAMETERS AFFECTING THE ACTIVITY OF MONOAMINE OXIDASE IN PURIFIED BOVINE BRAIN MITOCHONDRIA 1
TLDR
The inhibition of kynuramine and serotonin deamination was non‐competitive but mixed competitive inhibition was found with tyramine and phenylethylamine, and pyrophosphate ion had little or no effect on MAO activity, regardless of substrate.
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References

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TLDR
The hyperactivity and hyperpyrexia produced by l‐tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by chlorpromazine, and Pretreatment of rats with p‐chlorophenylalanine did not inhibit hyperactivity produced by 5‐MeODMT.
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TLDR
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