EVIDENCE FOR USE OF CHROMIUM IN TREATMENT OF PRE-DIABETES

@article{Wright2014EVIDENCEFU,
  title={EVIDENCE FOR USE OF CHROMIUM IN TREATMENT OF PRE-DIABETES},
  author={Nicholas J Wright and Tracy S. Hunter},
  journal={Journal of Pharmaceutical and Scientific Innovation},
  year={2014},
  volume={3},
  pages={298-305}
}
Chromium supplements are widely used for the prevention and treatment of type 2 diabetes. Recent conflicting reports on its varying effects across different patient demographics calls for a review of the evidence to clarify the role of chromium supplementation in the prevention and management of elevated fasting glucose levels. A search of the literature performed with the terms chromium, pre-diabetes, type 2 diabetes continues to yield conflicting results due to small sample sizes… 

References

SHOWING 1-10 OF 111 REFERENCES
Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity
TLDR
Chromium therapy did not improve insulin sensitivity in non-obese normoglycemic individuals and subjects who have high serum chromium levels paradoxically had a decline in insulin sensitivity, so caution should be exercised in recommending the use of this supplement.
Role of Chromium in Human Health and in Diabetes
TLDR
This review focuses on providing current information about this trace mineral’s specific mechanisms of action and clinical trials in patients with diabetes, and elucidating the cellular and molecular mechanisms by which chromium supplements affect carbohydrate metabolism in vivo is necessary.
Effects of supplemental chromium on patients with symptoms of reactive hypoglycemia.
TLDR
Chromium supplementation alleviated the hypoglycemic symptoms and significantly raised the minimum serum glucose values observed two to four hours following a glucose load, suggesting that impaired Cr nutrition and/or metabolism may be a factor in the etiology of hypoglycemia.
Effect of Chromium Supplementation on Glucose Metabolism and Lipids
TLDR
Chromium supplementation significantly improved glycemia among patients with diabetes and in people without diabetes, however, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation.
Molecular mechanisms of chromium in alleviating insulin resistance.
TLDR
A review examines emerging reports on the effect of chromium, as well as molecular and cellular mechanisms by which chromium may provide beneficial effects in alleviating insulin resistance.
Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus.
TLDR
Chromium may reduce myocellular lipids and enhance insulin sensitivity in subjects with type 2 diabetes mellitus who do respond clinically independent of effects on weight or hepatic glucose production, and modulation of lipid metabolism by Cr in peripheral tissues may represent a novel mechanism of action.
Chromium, glucose intolerance and diabetes.
  • R. Anderson
  • Medicine
    Journal of the American College of Nutrition
  • 1998
Within the last 5 years chromium (Cr) has been shown to play a role in glucose intolerance, Type 2 diabetes mellitus (Type 2 DM), and gestational diabetes. In addition, diabetes and the neuropathy of
Elevated Intakes of Supplemental Chromium Improve Glucose and Insulin Variables in Individuals With Type 2 Diabetes
TLDR
It is demonstrated that supplemental chromium had significant beneficial effects on HbA1c, glucose, insulin, and cholesterol variables in subjects with type 2 diabetes and was observed at levels higher than the upper limit of the Estimated Safe and Adequate Daily Dietary Intake.
Essentiality of chromium in humans.
  • R. Anderson
  • Medicine
    The Science of the total environment
  • 1989
TLDR
Well controlled studies involving human subjects have demonstrated beneficial effects of supplemental chromium on fasting glucose, glucose tolerance, blood lipids, insulin binding, and hypoglycemic blood glucose values and symptoms.
Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-α, oxidative stress, and insulin resistance in type 2 diabetic subjects: randomized, double-blind, placebo-controlled study.
TLDR
CDNC supplementation lowers insulin resistance by reducing blood levels of TNF-α, insulin, and oxidative stress in type 2 diabetic subjects, suggesting that CDNC supplementation has potential as an adjunct therapy for individuals with type 2 diabetes.
...
1
2
3
4
5
...