EVI1 expression in childhood acute lymphoblastic leukaemia is not restricted to MLL and BCR/ABL rearrangements and is influenced by age

Abstract

EVI1 is a transcriptional regulator with an important function in haematopoiesis and self-renewal. Aberrant overexpression of EVI1 has been firmly established as one of the most adverse prognostic markers in acute myeloid leukaemia (AML), implying that EVI1 is one of the most aggressive oncogenes in AML. Importantly, a recent report in Leukemia from Konantz… (More)
DOI: 10.1038/bcj.2013.76

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