author={Bernard S. Bloom and Aur{\'e}lia Retbi and Sonia Dahan and E Jonsson},
  journal={International Journal of Technology Assessment in Health Care},
  pages={13 - 21}
  • B. BloomA. Retbi E. Jonsson
  • Published 1 January 2000
  • Medicine
  • International Journal of Technology Assessment in Health Care
Objectives: Use of complementary and alternative medicine (CAM) is growing in all Western countries. The goal of this study was to evaluate quality of randomized controlled trials (RCTs) of CAM interventions for specific diagnoses to inform clinical decision making. Methods: MEDLINE and related databases were searched for CAM RCTs. Visual review was done of bibliographies, meta-analyses, and CAM journals. Inclusion criteria for review and scoring were blinded RCT, specified diagnosis and… 

Complementary and alternative medicine in the scientific literature.

There is an upward trend in the number of CAM articles but the numberOf experimental studies is low and over half of articles are published in journals without an IF and there is an urgent need to conduct rigorous research in the field of CAM.

Usefulness of US Cost-of-Illness Studies in Healthcare Decision Making

The wide variation of cost estimates for the same diagnosis raises serious questions of comparability, accuracy, validity and usefulness of all studies.

Association of journal quality indicators with methodological quality of clinical research articles.

High citation rates, impact factors, and circulation rates, and low manuscript acceptance rates and indexing on Brandon/Hill Library List appear to be predictive of higher methodological quality scores for journal articles.

Spinal palpation: The challenges of information retrieval using available databases.

Use of Complementary and Alternative Medicine and Self-Rated Health Status: Results from a National Survey

A significant association between CAM use and self-rated excellent health and health improvement over the prior year is found.

Foundations of Methodology in Integrative Mental Health Care

  • J. Lake
  • Medicine, Psychology
    An Integrative Paradigm for Mental Health Care
  • 2019
Current research and clinical methodologies in mental health care are reviewed and critiqued and mixed methods research designs that combine quantitative and qualitative research methods may help elucidate complex dynamic interactions between synergistic factors that influence outcomes in response to integrative treatment regimens.

What is this nonsense that complementary and alternative medicine is not amenable to controlled investigation of population effects?

  • B. Bloom
  • Medicine
    Academic medicine : journal of the Association of American Medical Colleges
  • 2001
The issue of the probability that an intervention works to achieve a desired health outcome, and how that probability is established is examined, and the issue of who pays for the intervention, and under what circumstances is examined.

Complementary and alternative medicine in gastroenterology: the good, the bad, and the ugly.

  • R. KoretzM. Rotblatt
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2004

Statistical Reanalysis of Four Recent Randomized Trials of Acupuncture for Pain Using Analysis of Covariance

  • A. Vickers
  • Medicine
    The Clinical journal of pain
  • 2004
Reanalysis found acupuncture to be effective and that its effectiveness could not be ascribed to a placebo effect, and future trials of acupuncture and other modalities for pain should use efficient statistical methods.



Discrepancies between meta-analyses and subsequent large randomized, controlled trials.

The outcomes of the 12 large randomized, controlled trials that were studied were not predicted accurately 35 percent of the time by the meta-analyses published previously on the same topics.

Efficacy of Spinal Manipulation/Mobilization Therapy: A Meta-Analysis

Data analysis indicated that studies not employing random assignment were more likely to produce results supporting the use of manipulation/mobilization therapies and hypotheses tests appearing in journals published in the United States showed manipulation/ mobilization less effective.

A method for assessing the quality of a randomized control trial.

Large trials vs meta-analysis of smaller trials: how do their results compare?

Results of smaller studies are usually compatible with the results of large studies, but discrepancies do occur even when the diversity among both large studies and smaller studies is considered.

Some methodological problems in the assessment of complementary therapy.

  • H. Anthony
  • Medicine, Psychology
    Statistics in medicine
  • 1987
The paper raises the question of whether the main problems in trial design are only problems for complementary medicine, and the problems are examined and alternative approaches suggested.

Issues in comparisons between meta-analyses and large trials.

To evaluate protocols comparing meta-analyses and large trials in order to understand if and why they disagree on the concordance of these 2 clinical research methods, systematic comparison of protocol designs, study selection, definitions of agreement, analysis methods, and reported discrepancies are evaluated.

Prevalence and cost of alternative medicine in Australia

Use of alternative health care by family practice patients.

Open and nonjudgmental questioning of patients may help increase physician knowledge of this use of alternative medicine and lead to improved patient care as physicians and patients work together toward health.