• Corpus ID: 56454905

EVALUATION OF EFFECTS OF RUTIN ON OXIDATIVE STRESS IN DIABETIC RAT

@inproceedings{Bais2012EVALUATIONOE,
  title={EVALUATION OF EFFECTS OF RUTIN ON OXIDATIVE STRESS IN DIABETIC RAT},
  author={S. K. Bais and G Y Shende and Avinash Jiddewar},
  year={2012}
}

• S. Bais, G. Shende, Avinash Jiddewar
• Published 2012
• Biology

Oxidative stress which usually results from excessive production of ROS and/or diminished activity of antioxidants have been implicated as a major contributor to the etiology of severe pathologies, including diabetes. Moreover, increasing evidence shows that excess ROS acts as negative regulators of insulin signaling leading to insulin resistance, a known metabolic abnormality associated with diabetes. Oxidative stress is currently suggested as a mechanism underlying diabetes and diabetic complications. Enhanced oxidative stress and changes in antioxidant capacity, observed in both clinical and experimental diabetes mellitus, are thought to be the etiology of chronic diabetic complications. In recent years, much attention has been focused on the role of oxidative stress, and it has been reported that oxidative stress may constitute the key and common event in the pathogenesis of secondary diabetic complications. We observed a significant increase in Superoxide dismutase (SOD) and Catalase activity with the exception, an increase in activity of LPO (Lipidperioxidase) as compared to the control subjects. Rutin improved SOD and Catalase activity in diabetic rat with gastropathy when compared with the normal rat treated with vehicle. NSPM, College of Pharmacy, Darwha, Dist Yavatmal, India. Email: [e-mail]