EVALUATION OF CUPRIMINE® AND SYPRINE® FOR DECORPORATION OF RADIOISOTOPES OF CESIUM, COBALT, IRIDIUM AND STRONTIUM

@article{Levitskaia2011EVALUATIONOC,
  title={EVALUATION OF CUPRIMINE{\textregistered} AND SYPRINE{\textregistered} FOR DECORPORATION OF RADIOISOTOPES OF CESIUM, COBALT, IRIDIUM AND STRONTIUM},
  author={Tatiana G. Levitskaia and Jeffrey A. Creim and Terry L. Curry and Teresa Luders and James M. Peterson and Karla D. Thrall and Barry L. Levinson},
  journal={Health Physics},
  year={2011},
  volume={101},
  pages={118-127}
}
Cuprimine® and Syprine® are therapeutics approved by the USFDA to treat copper overload in Wilson Disease (a genetic defect in copper transport) by chelation and accelerated excretion of internally-deposited copper. These oral therapeutics are based on the respective active ingredients D-penicillamine (DPA) and N,N′-bis (2-aminoethyl) -1,2-ethanediamine dihydrochloride (Trien). Cuprimine is considered the primary treatment, although physicians are increasingly turning to Syprine as a first-line… Expand
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