ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.

@article{Vokuhl2018ETV6NTRK3IC,
  title={ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.},
  author={Christian Vokuhl and Nasenien Nourkami-Tutdibi and Rhoikos Furtw{\"a}ngler and Manfred Gessler and Norbert Graf and Ivo Leuschner},
  journal={Pediatric blood & cancer},
  year={2018},
  volume={65 4}
}
BACKGROUND Congenital mesoblastic nephroma (MN) is a rare pediatric renal tumor representing approximately 5% of all pediatric renal tumors. Three different types of MN are distinguished histologically: classical, cellular, and mixed. A frequent genetic alteration is the translocation t(12;15) resulting in a fusion of the ETV6 gene on 12p13 and the NTRK3 gene on 15p15 that occurs almost exclusively in cellular MN. The aim of this study was to determine translocation status of a large cohort of… CONTINUE READING