ETV6/RUNX1 Rearrangement Identified by RT-PCR without Evidence on FISH

@article{Hahm2014ETV6RUNX1RI,
  title={ETV6/RUNX1 Rearrangement Identified by RT-PCR without Evidence on FISH},
  author={Chorong Hahm and Sung Hee Han and Yeung Chul Mun and Chu Myong Seong and Wha Soon Chung and Jungwon Huh},
  journal={Acta Haematologica},
  year={2014},
  volume={132},
  pages={122 - 124}
}
were performed on unstimulated 24and 48-hour cultures, using fresh bone marrow aspirates. Karyotypes were described according to the International System for Human Cytogenetic Nomenclature (ISCN; 2009) [4] . Metaphase cytogenetics revealed a normal karyotype, 46,XX[10]. Interphase FISH using ETV6 dual color, break-apart rearrangement probe (Abbott/Vysis, Downers Grove, Ill., USA) showed 13% ETV6 deletion without any evidence of ETV6 rearrangement: nuc ish(ETV6x1) [25/200] (cut-off 0.6%; fig. 1… CONTINUE READING

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