ETV4 is a useful marker for the diagnosis of CIC-rearranged undifferentiated round-cell sarcomas: a study of 127 cases including mimicking lesions

@article{Guellec2016ETV4IA,
  title={ETV4 is a useful marker for the diagnosis of CIC-rearranged undifferentiated round-cell sarcomas: a study of 127 cases including mimicking lesions},
  author={Sophie L E Guellec and Val{\'e}rie V{\'e}lasco and Ga{\"e}lle P{\'e}rot and Sarah Watson and Franck Tirode and J. M. Coindre},
  journal={Modern Pathology},
  year={2016},
  volume={29},
  pages={1523-1531}
}
Subsets of primitive round-cell sarcomas remain difficult to diagnose and classify. Among these is a rare round-cell sarcoma that harbors a CIC gene rearrangement known as CIC-rearranged undifferentiated round-cell sarcoma, which is most commonly fused to the DUX4 gene. Owing to its aggressive clinical behavior and potential therapeutic implications, accurate identification of this novel soft tissue sarcoma is necessary. Definitive diagnosis requires molecular confirmation, but only a few… CONTINUE READING