ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.

@article{Baena2013ETV1DA,
  title={ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.},
  author={Esther Baena and Zhen Shao and Douglas E. Linn and Kimberly Glass and Melanie J. Hamblen and Yuko Fujiwara and Jonghwan Kim and Minh Nguyen and Xin Zhang and Frank J. Godinho and Roderick Terry Bronson and Lorelei A. Mucci and Massimo F. Loda and Guocheng Yuan and Stuart H Orkin and Zhe Li},
  journal={Genes & development},
  year={2013},
  volume={27 6},
  pages={
          683-98
        }
}
Distinguishing aggressive from indolent disease and developing effective therapy for advanced disease are the major challenges in prostate cancer research. Chromosomal rearrangements involving ETS transcription factors, such as ERG and ETV1, occur frequently in prostate cancer. How they contribute to tumorigenesis and whether they play similar or distinct in vivo roles remain elusive. Here we show that in mice with ERG or ETV1 targeted to the endogenous Tmprss2 locus, either factor cooperated… CONTINUE READING

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