ETV/Pea3 family transcription factor-encoding genes are overexpressed in CIC-mutant oligodendrogliomas.

@article{Padul2015ETVPea3FT,
  title={ETV/Pea3 family transcription factor-encoding genes are overexpressed in CIC-mutant oligodendrogliomas.},
  author={Vijay Padul and Sridhar Epari and Aliasgar Vajihuddin Moiyadi and Prakash M. Shetty and Neelam Vishwanath Shirsat},
  journal={Genes, chromosomes & cancer},
  year={2015},
  volume={54 12},
  pages={
          725-33
        }
}
Oligodendrogliomas with combined loss of chromosome arms 1p and 19q are known to be particularly sensitive to chemotherapy, and the CIC gene located on 19q is known to be mutated in over 50% of the 1p/19q codeleted oligodendrogliomas. However, the role of CIC in the oligodendroglioma pathogenesis is not known. Exome sequencing of 11 oligodendroglial tumors identified 9 tumors with combined loss of 1p and 19q. Somatic mutations were found in the CIC and FUBP1 genes. Recurrent somatic mutations… CONTINUE READING
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