ETS gene fusions in prostate cancer: from discovery to daily clinical practice.

@article{Tomlins2009ETSGF,
  title={ETS gene fusions in prostate cancer: from discovery to daily clinical practice.},
  author={Scott Arthur Tomlins and Anders Bjartell and Arul M. Chinnaiyan and Guido Jenster and Robert K. Nam and Mark A. Rubin and Jack A Schalken},
  journal={European urology},
  year={2009},
  volume={56 2},
  pages={275-86}
}
CONTEXT In 2005, fusions between the androgen-regulated transmembrane protease serine 2 gene, TMPRSS2, and E twenty-six (ETS) transcription factors were discovered in prostate cancer. OBJECTIVE To review advances in our understanding of ETS gene fusions, focusing on challenges affecting translation to clinical application. EVIDENCE ACQUISITION The PubMed database was searched for reports on ETS fusions in prostate cancer. EVIDENCE SYNTHESIS Since the discovery of ETS fusions, novel 5' and… CONTINUE READING
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