ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target.

  title={ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target.},
  author={O. Koray Demir and Neşe Ayşit and Zeynep Onder and Nezaket Turkel and Gurkan Ozturk and Andrew D Sharrocks and Isil Aksan Kurnaz},
  journal={Biochimica et biophysica acta},
  volume={1812 6},
Elk-1 belongs to the ternary complex factors (TCFs) subfamily of the ETS domain proteins, and plays a critical role in the expression of immediate-early genes (IEGs) upon mitogen stimulation and activation of the mitogen-activated protein kinase (MAPK) cascade. The association of TCFs with serum response elements (SREs) on IEG promoters has been widely studied and a role for Elk-1 in promoting cell cycle entry has been determined. However, the presence of the ETS domain transcription factor Elk… CONTINUE READING


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