ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I.

@article{Leroy2006ETR3RT,
  title={ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I.},
  author={Olivier Leroy and C M Dhaenens and Suzanna Schraen-Maschke and Karim B{\'e}larbi and Andr{\'e} Delacourte and Athena Andreadis and Bernard Sablonni{\'e}re and Luc Bu{\'e}e and Nicolas Sergeant and Marie-Laure Caillet-Boudin},
  journal={Journal of neuroscience research},
  year={2006},
  volume={84 4},
  pages={852-9}
}
Altered splicing of transcripts, including the insulin receptor (IR) and the cardiac troponin (cTNT), is a key feature of myotonic dystrophy type I (DM1). CELF and MBNL splicing factor members regulate the splicing of those transcripts. We have previously described an alteration of Tau exon 2 splicing in DM1 brain, resulting in the favored exclusion of exon 2. However, the factors required for alternative splicing of Tau exon 2 remain undetermined. Here we report a decreased expression of CELF… CONTINUE READING

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