ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.

@article{AragonesesFenoll2016ETP46321AD,
  title={ETP-46321, a dual p110$\alpha$/$\delta$ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.},
  author={L. Aragoneses-Fenoll and M. Montes-Casado and G. Ojeda and Y. Y. Acosta and J. Herranz and S. Mart{\'i}nez and C. Blanco-Aparicio and G. Criado and J. Pastor and U. Dianzani and P. Portol{\'e}s and J. Rojo},
  journal={Biochemical pharmacology},
  year={2016},
  volume={106},
  pages={
          56-69
        }
}
Class IA phosphoinositide 3-kinases (PI3Ks) are essential to function of normal and tumor cells, and to modulate immune responses. T lymphocytes express high levels of p110α and p110δ class IA PI3K. Whereas the functioning of PI3K p110δ in immune and autoimmune reactions is well established, the role of p110α is less well understood. Here, a novel dual p110α/δ inhibitor (ETP-46321) and highly specific p110α (A66) or p110δ (IC87114) inhibitors have been compared concerning T cell activation in… Expand
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Targeting the class IA PI3K isoforms p110α/δ attenuates heart allograft rejection in mice by suppressing the CD4+ T lymphocyte response.
Inhibition of the α-Subunit of Phosphoinositide 3-Kinase in Heart Increases Late Sodium Current and Is Arrhythmogenic
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