ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2

@inproceedings{Ghosh2014ETOFP,
  title={ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2},
  author={Hiyaa Singhee Ghosh and Michele Ceribelli and In{\^e}s Matos and Allan Lazarovici and Harmen J. Bussemaker and Anna Lasorella and Scott W Hiebert and Kang Liu and Louis M. Staudt and Boris Reizis},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
Dendritic cells (DCs) comprise two major subsets, the interferon (IFN)-producing plasmacytoid DCs (pDCs) and antigen-presenting classical DCs (cDCs). The development of pDCs is promoted by E protein transcription factor E2-2, whereas E protein antagonist Id2 is specifically absent from pDCs. Conversely, Id2 is prominently expressed in cDCs and promotes CD8(+) cDC development. The mechanisms that control the balance between E and Id proteins during DC subset specification remain unknown. We… CONTINUE READING
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