ETA receptors mediate vasoconstriction of large conduit arteries during reduced flow in humans.

@article{Spieker2003ETARM,
  title={ETA receptors mediate vasoconstriction of large conduit arteries during reduced flow in humans.},
  author={Lukas E. Spieker and Thomas Felix L{\"u}scher and Georg Noll},
  journal={Journal of cardiovascular pharmacology},
  year={2003},
  volume={42 3},
  pages={315-8}
}
Vascular tone is regulated by endothelium-derived vasodilating and constricting substances, mainly nitric oxide and endothelin (ET)-1. These 2 mediators, which antagonize the actions of each other, are released in response to shear-stress produced by blood flow. The aim of this study was to delineate the contribution of endogenous ET-1 on vascular tone of a large conduit artery during reduced and hyperemic flow. Radial artery diameter was continuously measured with a high-resolution ultrasonic… CONTINUE READING