ET-1 and NOS III gene expression regulation by plaque-free and plaque-prone hemodynamic conditions.

@article{Mattart2003ET1AN,
  title={ET-1 and NOS III gene expression regulation by plaque-free and plaque-prone hemodynamic conditions.},
  author={M{\'e}lanie Mattart and Lucia Mazzolai and C{\'e}line Chambaz and Daniel Hayoz and Hans Rudolf Brunner and Paolo Silacci},
  journal={Biorheology},
  year={2003},
  volume={40 1-3},
  pages={289-97}
}
Both plaque-free and plaque-prone hemodynamic environments induce an increase in the oxidative state of endothelial cells (ECs), whereas differential gene expression regulation was described in cells exposed to these conditions. In order to investigate the role of the increased oxidative state in flow-regulation of gene expression, we first exposed EC to non-pulsed unidirectional shear stress. These conditions only slightly increases ECs oxidative state and endothelin-1 (ET-1) mRNA expression… CONTINUE READING