ET(A) receptor blockade protects the small intestine against ischaemia/reperfusion injury in dogs via an enhancement of antioxidant defences.

@article{Andrsi2002ETARB,
  title={ET(A) receptor blockade protects the small intestine against ischaemia/reperfusion injury in dogs via an enhancement of antioxidant defences.},
  author={Ter{\'e}zia Bogdana Andr{\'a}si and Violetta K{\'e}kesi and Anna Bl{\'a}zovics and Istv{\'a}n D{\'o}bi and G{\'a}bor Sz{\'a}bo and Alexander Juh{\'a}sz-Nagy},
  journal={Clinical science},
  year={2002},
  volume={103 Suppl 48},
  pages={59S-63S}
}
The aim of the present study was to determine whether the ET(A) receptor antagonist LU135252 can protect the mesenterium against ischaemia/reperfusion (I/R) damage. Direct occlusion of the superior mesenteric artery was performed for 30 min in two groups of dogs. Declamping was followed by 90 min of reperfusion. Mesenteric release of ET-1 was studied in series 1 (n=6). In series 2, 5 min before cross-clamping, the treated group (n=7) received an intravenous bolus of LU135252 (5 mg/kg), whereas… CONTINUE READING