ESX secretion systems: mycobacterial evolution to counter host immunity.

  title={ESX secretion systems: mycobacterial evolution to counter host immunity.},
  author={Matthias I P Gr{\"o}schel and Fadel Sayes and Roxane Sim{\'e}one and Laleh Majlessi and Roland Brosch},
  journal={Nature reviews. Microbiology},
  volume={14 11},
Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as type VII secretion systems), to export a set of effector proteins that helps the pathogen to resist or evade the host immune response. Since the discovery of the esx loci during the M. tuberculosis H37Rv genome project, structural biology, cell biology and evolutionary analyses have advanced our knowledge of the function of… CONTINUE READING
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