ESR1 gene amplification in breast cancer: a common phenomenon?

  title={ESR1 gene amplification in breast cancer: a common phenomenon?},
  author={Hugo M. Horlings and Anna Bergamaschi and Silje H. Nordgard and Young Hwan Kim and Wonshik Han and Dong-Young Noh and Keyan Salari and Simon Andreas Joosse and Fabien Reyal and Ole Christian Lingjaerde and Vessela N. Kristensen and Anne-Lise B\orresen-Dale and Jonathan Pollack and Marc J. van de Vijver},
  journal={Nature Genetics},
nature genetics | volume 40 | number 7 | july 2008 807 ence channel at the ESR1 locus and found no evidence of CNV. Thus, CNV is unlikely to be the explanation for the discrepancy. The key difference between our study and that of Holst et al.1 is the methodology for scoring FISH-TMA (manual vs. automated) and the criteria used to call amplifications. Holst et al.1 scored as amplified not only cases with an ESR1 to centromere 6 ratio ≥2 but also “tumors with tight signal clusters...independent… CONTINUE READING
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Genes Chromosom

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Table 1 Available acGH data for ESR1 locus 6q25.1 and ERBB2 (HER2) locus 17q12 ESR1 copy number Total ESR1 No. probes on array CGH Reference Total cases Available cases Ampl

  • K Al Kuraya
  • Cancer Res
  • 2004

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