ESET histone methyltransferase regulates osteoblastic differentiation of mesenchymal stem cells during postnatal bone development.

@article{Lawson2013ESETHM,
  title={ESET histone methyltransferase regulates osteoblastic differentiation of mesenchymal stem cells during postnatal bone development.},
  author={Kevin A. Lawson and Colin J. Teteak and Jidi Gao and Ning Li and Jacques H. Hacquebord and Andrew C Ghatan and Anna Zielinska-Kwiatkowska and Guangchun Song and Howard A. Chansky and Liu Yang},
  journal={FEBS letters},
  year={2013},
  volume={587 24},
  pages={
          3961-7
        }
}
To investigate the effects of histone methyltransferase ESET (also known as SETDB1) on bone metabolism, we analyzed osteoblasts and osteoclasts in ESET knockout animals, and performed osteogenesis assays using ESET-null mesenchymal stem cells. We found that ESET deletion severely impairs osteoblast differentiation but has no effect on osteoclastogenesis, that co-transfection of ESET represses Runx2-mediated luciferase reporter while siRNA knockdown of ESET activates the luciferase reporter in… CONTINUE READING
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