ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting

@inproceedings{Shields2009ESCRTUD,
  title={ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting},
  author={S. Brookhart Shields and Andrea J. Oestreich and Stanley C. Winistorfer and Doris Nguyen and Johanna A. Payne and David J. Katzmann and Robert Piper},
  booktitle={The Journal of cell biology},
  year={2009}
}
Ubiquitin (Ub) sorting receptors facilitate the targeting of ubiquitinated membrane proteins into multivesicular bodies (MVBs). Ub-binding domains (UBDs) have been described in several endosomal sorting complexes required for transport (ESCRT). Using available structural information, we have investigated the role of the multiple UBDs within ESCRTs during MVB cargo selection. We found a novel UBD within ESCRT-I and show that it contributes to MVB sorting in concert with the known UBDs within the… CONTINUE READING
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