ESCRT regulates surface expression of the Kir2.1 potassium channel

@inproceedings{Kolb2014ESCRTRS,
  title={ESCRT regulates surface expression of the Kir2.1 potassium channel},
  author={Alexander R. Kolb and Patrick G. Needham and Cari Rothenberg and Christopher J. Guerriero and Paul A Welling and Jeffrey L Brodsky},
  booktitle={Molecular biology of the cell},
  year={2014}
}
Protein quality control (PQC) is required to ensure cellular health. PQC is recognized for targeting the destruction of defective polypeptides, whereas regulated protein degradation mechanisms modulate the concentration of specific proteins in concert with physiological demands. For example, ion channel levels are physiologically regulated within tight limits, but a system-wide approach to define which degradative systems are involved is lacking. We focus on the Kir2.1 potassium channel because… CONTINUE READING

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