ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.

  title={ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.},
  author={Amy J Curwin and Nathalie Brouwers and Manuel Alonso Y Adell and David Teis and Gabriele Turacchio and Seetharaman Parashuraman and Paolo Ronchi and Vivek Malhotra},
The unconventional secretory pathway exports proteins that bypass the endoplasmic reticulum. In Saccharomyces cerevisiae, conditions that trigger Acb1 secretion via this pathway generate a Grh1 containing compartment composed of vesicles and tubules surrounded by a cup-shaped membrane and collectively called CUPS. Here we report a quantitative assay for Acb1 secretion that reveals requirements for ESCRT-I, -II, and -III but, surprisingly, without the involvement of the Vps4 AAA-ATPase. The… CONTINUE READING

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O Avinoam, M Schorb, CJ Beese, JA Briggs, M. Kaksonen
endocytic sites mature by continuous bending and remodeling of the clathrin coat. Science 348:1369–1372. doi: 10.1126/science. aaa9555 • 2015
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